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After 1 week, erythromycin 1000 mg a day gradually increase to target dosage (2400 mg/day) according to the following schedule: 300 mg twice daily for 1 week, 300 mg twice daily with 600 mg at bedtime for 2 weeks, 600 mg 3 times daily for 2 weeks, and 600 mg twice daily with 1200 mg at bedtime.

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